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Description
One of these nucleophilic species is glutathione, a tripeptide that is synthesized in the cytosol from glutamic acid, cysteine and glycine, that exists in thiol-reduced (GSH) and disulfide-oxidized (GSSG) forms, with the former representing around 98% of intracellular glutathione under physiological conditions 29
This mechanism is especially important in disorders of mitochondrial fatty acids oxidation, when fatty acyl-CoAs accumulate in organs such as the heart inducing apoptosis and inflammation [5]
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mTORC1 as a regulator of mitochondrial functions and a therapeutic target in cancer
