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This is largely due to the unique biological and clinical characteristics of GB, including dynamic evaluation of the tumor, its highly heterogeneous tumor microenvironment, and poor drug penetration through BBB, as illustrated in Figure 3

Quantification of the volume of BBB disruption indicated by the T1 weighted, gadoliniumenhanced images revealed no significant differences between the untreated TBI group and the Immunocal-pretreated TBI group (Figure 1C)

108 The AD brain is characterized by abnormal neuronal copper distribution, with accumulation of copper in amyloid plaques and deficiency in the cells

This results in shorter times needed for diffusion