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Intraperitoneal injection of ozone reduces the expression of APP in AD, reducing the deposition of A and slowing the progression of pathological changes in AD.90,128 A overproduction is the core event in AD and drives downstream pathologies, including tau neurochemical changes, central inflammation, excitotoxicity, neurofibrillary tangle neurochemical changes, and neuronal death.129 Therefore, ozone may exert therapeutic effects on AD by reducing A deposition and alleviating neuroinflammation