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Under serine deprivation, ATF4 is induced and activates the transcription of SSP-related genes
15,16 On the other hand, TRX reductase (TRXR) utilizes NADPH as an electron donor to maintain the reduced form of TRX, which contributes to scavenge H 2 O 2 and reduce ribonucleotide reductase (RNR) for DNA synthesis
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Persistent headaches at low doses are a reason to pause and reassess
