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Increased acetaldehyde and the associated free radical damage (called ROS) is the mechanism that drives these symptoms

For example, Cys (239), one of the six cysteinyl residues, is poorly accessible when Hsp 33 is active, and remains reduced despite H2O2 exposure, and does not therefore react with the sixth cysteinyl, Cys (141 ), which is highly reactive toward chemical modifications, demonstrating that other factors such as amino acid sequence, and other amino acid/peptidyl properties also are important in protein folding
Wang, F., Tang, H., Zhu, J

rather, they feel chronically fatigued despite adequate amounts of sleep
