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During bortezomib therapy, peripheral neuropathy occurred in 21% of patients receiving 1.0 mg/m 2 per dose and in 37% receiving 1.3 mg/m 2

This disruption is believed to interfere with melatonin production, a hormone with oncostatic properties, thereby increasing cancer susceptibility [40]

In the hepatocyte cytosol, where the NAD + concentration is high, lactate is oxidized to pyruvate by the liver isoenzyme of lactate dehydrogenase (EC 1.1.1.27)

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