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Description
It has an hepatic metabolism, mainly because of the glucuro-conjugation of the molecule, with the formation of inactive metabolites

These fractures impair quality of life and are associated with increased mortality

Tirzepatide monotherapy demonstrates 2022% average body weight reduction in clinical trials, with robust appetite suppression through dual GIP/GLP-1 activation

Moreover, data are more abundant for the peripheral expression and function of these transporters, and less is known about the BBB, with the exception perhaps of the P-gp
