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demonstrated that AS-IV reduces ROS accumulation in ISO-induced cardiomyocytes, mitigates mitochondrial membrane damage, counters Ca 2+ redistribution due to oxidative stress, inhibits calpain-1 activation, maintains calcium homeostasis, and prevents apoptosis in ISO-induced myocardial hypertrophy, reducing arrhythmia risk (Mei et al., 2015)

[PMC free article: PMC6409061] [PubMed: 30915365] 158

Synaptic proteins, neuropathology and cognitive status in the oldest-old

The structural similarity between autoantigens and bacterial antigens in the colon may lead to antigenic mimicry that stimulates plasma cells to produce antibodies