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Longer use may blunt responsiveness due to IGF-1 receptor downregulation
Recruitment of beta arrestins desensitizes both receptors, and this is followed by internalization, recycling, and inactivation of Gas

An allosteric drug, o,o-bismyristoyl thiamine disulfide, suppresses HIV-1 replication through prevention of nuclear translocation of both HIV-1 Tat and NF-kappa B Biochem Biophys Res Commun 1998 249 : 745753 Bentires-Alj M, Hellin AC, Ameyar M, Chouaib S, Merville MP, Bours V

Vila et al., 2000
