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Description
DNA damage, caused by free radicals (ROS that have not been buffered by anti-oxidants) and inadequate repair mechanisms, disrupts gene regulation, leading to cell death or senescence [23,24,25]

PLoS One 19 (1), e0296259

Barlow-Walden LR, Reiter RJ, Abe M, Pablos M, Menendez-Pelaez A, Chen LD, Poeggeler B
NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis
