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Alcohol and smoking deplete glutathione levels and reduce supplement effectiveness

CaladaDVianelloDGiampieriESalaCCastellaniGde GraafAet alThe role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach

Additionally, in diabetic wounds, glucose metabolism is impaired due to insulin resistance and defective glucose uptake, which exacerbates the inhibition of mitochondrial oxidative phosphorylation and glycolysis, and leads to insufficient ATP production and subsequent mitochondrial dysfunction

While the status of screening for these polymorphisms remains to be established, uncovering the molecular mechanisms responsible for the dysregulation in GSH synthesis may provide novel therapeutic approaches