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Single-Cell Mass Cytometry Characterizes Phenotypic and Functional Heterogeneity in Acute Myeloid Leukemia at Diagnosis, in Remission and Relapse

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In another preclinical GBM study, the EGFR TKI gefitinib was effective in attenuating downstream MAPK/MEK/ERK activity, but concurrent inhibition of EGFR and IGF-1R/INSR was required to suppress Akt and induce apoptosis [105]

For cysteine reactivity profiling experiments, peptide ratios (signal intensity/sum of signal intensities per peptide) were calculated and cysteine aggregation was performed to aggregate signal intensities for multiple cysteines on the same peptide and multiple peptides for the same cysteine