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Synergistic or antagonistic interactions between compounds can alter their individual pharmacokinetics, necessitating careful adjustments and extensive preliminary research for each compound
In preclinical studies, telaglenastat (CB-839), a Gln synthetase inhibitor, promoted the function of CD4 + Th 1 cells and CD8 + T cells, and inhibited the function of Th 17 cells
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Bone marrow adipocytes provide early sign for progression from MGUS to multiple myeloma
