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This imbalance of the gut microbiota and continued exposure of the colonic epithelial cells to urea is harmful to intestinal epithelial barrier function as it aids the disruption of the mucus layer and lowers the expression of tight junction proteins (Vaziri et al., 2013

J., Heffron, G., Metallo, C

However, copper accumulation negatively affects mitochondrial activity and may contribute to HF progression by reducing mitochondrial metabolism (Rines and Ardehali, 2013)

Yadav H, Sharma U, Singh S, Gupta Y (2019) Effect of Tribulus terrestris in mercuric chloride-induced renal accumulation of mercury and nephrotoxicity in rat