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MnSOD expression is also increased via SIRT3 activation in amyloid-beta (A)-treated models, where a novel rhamnoside derivative reduced ROS, restored mitochondrial integrity, and suppressed cellular senescence, reinforcing the MnSODSIRT3 axis as a promising neuroprotective pathway in AD [220]
Together, they can produce greater GH elevation than either alonethis is called synergy
