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Actually, serum level of methionine is dramatically increased in LIHC patients compared with healthy subjects [110, 111], and mice lacking Mat1a have reduced hepatic SAM levels and developed oxidative stress, steatohepatitis, and hepatocellular carcinoma [112]
J Biol Chem (1997) 272(28):17694702.10.1074/jbc.272.28.17694 140 StofegaMRHerringtonJBillestrupNCarter-SuC
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