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JAMA 290:17491756 Schnabel D, Grasemann C, Staab D, Wollmann H, Ratjen F, German cystic fibrosis growth hormone study group (2007) A multicenter, randomized, double-blind, placebo-controlled trial to evaluate the metabolic and respiratory effects of growth hormone in children with cystic fibrosis

This study tested ICA-1s stability, toxicity, pharmacokinetics, and therapeutic efficacy on in-vivo patients

Both apoptosis and autophagy are simultaneously activated by the distinct stressors

In contrast, the combination of a high bacterial load and an increased number of forkhead box protein 3 (FOXP3)-positive cells is a sign of poor prognosis