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Description
Indeed, high levels of GSH are observed in the majority of tumors, contributing to cancer progression and treatment resistance in part by preventing glutathione peroxidase 4dependent (GPX4-dependent) ferroptosis, an iron-dependent programmed cell death (5)
By advancing the accuracy and scalability of in vitro liver models, this work contributes to reducing reliance on animal testing and promoting ethical innovation in preclinical research, as emphasized by Ingelman-Sundberg and Lauschke 43
doi: 10.2174/1389450116666150907104742
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