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Additionally, chemotherapy and radiation therapy can significantly impact the hematopoietic system, with bone marrow suppression being one of the common side effects

CD36 is simultaneously a receptor for FFAs and is actively involved in the pathogenesis of endotheliosis and atherosclerosis, as well as in macrophage activation by endogenous factors, including as a co-receptor for TLR4, TLR6, and TLR2 [684,1114]

Thus, sertraline interferes with the function of the hypothalamicpituitarytesticular and hypothalamicpituitaryadrenal axes by affecting the wide distribution of serotonin receptors, thereby leading to reduced fertility in male rats (Figure 3)

In fact, it can create DNA strand breaks caused by the formation of NO-dependent reactive species such as peroxynitrite, which directly attack the DNA and cause failure to correct single-strand breaks, leading to the formation of double-strand breaks, which are probably responsible for cell death