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Aufgrund ihrer Fett- und Wasserlslichkeit ist sie besonders effektiv

[DOI] [PMC free article] [PubMed] [Google Scholar] 57.Fusco R., Siracusa R., Peritore A.F., Gugliandolo E., Genovese T., DAmico R., Cordaro M., Crupi R., Mandalari G., Impellizzeri D., et al

Low vitamin B12 has recently been linked to chronic migraine, and high homocysteine, with low cofactors and alterations in MTHFR (remember, the one that allowed the passage of THF to M-THF), has been linked to migraine with aura, due to incorrect methionine synthesis, which ultimately leads to an increase in homocysteine, causing an increase in reactive oxygen species (causing oxidative stress)

PMID 25732102