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High-dose vitamin B12 injections can cause immunologically induced skin reactions, which is why an amount adjusted to the individual blood level is recommended for supplementation among vegans to avoid possible vitamin B12 side effects

Vitamin B12 is reduced to cobalamin regardless of form (cyan-, methyl-, adenosyl-, hydroxo-) then re-assembled as methylcoblamin by MS for use in the cytosol, or adenosylcobalamin by MM for use in the mitochondria

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Additionally, B12 injections are used to treat the foot and ankle conditions below