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Taken together, these studies demonstrate that GPX1 and 2 have important roles in regulating the synthesis and release of proinflammatory mediators

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In eighteen relevant perioperative NAC meta-analyses, nine investigated the effect of NAC on renal function in cardiac surgery as the primary objective [33,35,37,38,41,44,47,48,66], three discussed general NAC use in cardiac surgery with frequent mention of renal outcomes [40,45,49], and two focused on renal outcomes in noncardiac surgery [43,46]

In melanoma cells, GSH depletion and GGT inhibition significantly increased cytotoxicity via oxidative stress [66]