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Description
3 GSH acts as a cofactor of GPX4, promoting the cellular reduction of phospholipid peroxides (PLOOHs) to non-toxic phospholipid alcohols (PLOHs), thereby alleviating cellular oxidative damage induced by ferroptosis
The lipid-rich outer hair cell membranes in the cochlea are especially vulnerable to the damaging effects of hydroxyl radicals, which can cause lipid peroxidation cascades that impair membrane integrity and cellular function [33]
Mabjeesh N
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