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Description
Furthermore, inhibiting TLR4 can also modulate gut microbiota homeostasis and the MyD88/NF-B axis in ulcerative colitis (164), indicating that TLR4 acts not only as a key sensor of innate immunity but may also regulate neuroimmune crosstalk and gut microenvironment homeostasis

Community reports suggest sleep disruption is less common with oral dosing, though no controlled comparison exists
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Common side effects include pain or redness at the injection site, mild diarrhea, itching, and swelling