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However, due to the off-target effect as a multi-kinase inhibitor [8], therapeutic advances are directed toward targeting metabolic vulnerabilities associated with SLC7A11 pathways in cancer

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A 2022 systematic review and meta-analysis of 18 randomized trials including 883 hypothyroid patients and evaluating outcomes like depression, fatigue, pain, anxiety, and anger, found no statistically significant advantage of combined LT4+LT3 therapy over LT4 monotherapy on any of these psychological endpoints (42)

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