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Description
For example, MC4R knockout mice exhibit significantly increased hypothalamic expression of neuropeptide Y (NPY) and agouti-related protein (AgRP), while pro-opiomelanocortin (POMC) expression is decreased compared with wild-type controls [56]

Typically, there's a lifting restriction of 5-10 kgs for 4-6 weeks

PLoS ONE 8:e70295

Its like youre running away from a grizzly bear
