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FEMS Microbiol Rev 25(3):335347 Chen L, Ma L, Bai Q, Zhu X, Zhang J, Wei Q et al (2014) Heavy metal-induced metallothionein expression is regulated by specific protein phosphatase 2A complexes

Alcohol is a particular concern, as it's thought to substantially lower the body's levels of this antioxidant

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Consequently, the anti-inflammatory M2 macrophages are converted to pro-inflammatory M1 macrophages, causing a cytokine storm known to cause endothelial tissue and organ damage in severe COVID-19 patients