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We investigated the longstanding idea that the onset of psychotic symptoms in schizophrenia arises from an early phase of glutamate neurotoxicity, possibly related to loss of GABA restraint, oxidative stress or inflammation, that cumulatively results in a later phase of synaptic loss in keeping with magnetic resonance spectroscopy (MRS) evidence of reduced glutamate in schizophrenia, especially in older patients

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The metabolism of sugars, fats, and amino acids in cancer cells is altered to fuel their unlimited growth, and these alterations are often brought about by epigenetic changes, such as changes in the three-dimensional structure of DNA