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In a body-composition substudy of participants averaging about 105 kg, roughly 75% of lost weight was fat and 25% was lean
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10.1152/physrev.00048.2006 216 YoshidaY.TakakuY.NakamotoY.TakayanagiN.YanagisawaT.TakizawaH.et al (2020)

This results in decreased autophagy and increased apoptosis, contributing to Schwann cell dysfunction
