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The mechanism appears to involve increased serotonin synthesis in substantia nigra (both compacta and reticulata), a regional pattern unlike any existing antidepressant drug, plus potential dopaminergic contributions given the nigrostriatal location

injections and procedures are not

Our laboratory has focused on an overlooked neurotrophic factor, hepatocyte growth factor (HGF), and found it to be more potent than BDNF when activated by angiotensin IV (AngIV) and AngIVbased analogs [37]

VEGF overexpression is especially critical, as tumor cells use it to drive angiogenesis around them, securing essential oxygen and nutrients for growth and metastasis [195]