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P300, CREB-binding protein (CBP), Pygo, BCL9, and other transcriptional co-activators are recruited for initiating transcription of Wnt target genes mediating the formation of the extracellular matrix, anti-apoptosis, cell proliferation ( CJUN , MYC , and CYD1 ) and angiogenesis ( VEGF and c-MET ) 18,19 ( Figure 1B )
