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Patient Characteristics Most patients in cohort 1 were female (62.2%), and the mean age was 70.4 years (standard deviation [SD],13.2)

Ideal candidates include individuals experiencing unexplained fatigue unresponsive to sleep and stress management, vegetarians and vegans lacking dietary B12 sources, adults over 50 with age-related absorption decline, patients with digestive disorders affecting nutrient absorption, those taking medications that deplete B12, and anyone seeking natural energy support without stimulants

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FoxO4 knockdown also reduced cell viability (Figure 4F) and increased the incidence of apoptosis among senescent TM3 Leydig cells (Figure 4G and 4H)