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Description
The pool of free CoA-SH decreases, so that free mitochondrial carnitine stores cannot be restored from acylcarnitine (including valproylcanitine) under the action of CPT2

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doi: 10.1053/j.jrn.2016.11.002

Moreover, dietary supplementation with TMAO significantly decreased the expression of both enteral cholesterol transporters Niemann-Pick C1-like1 (Npc1L1), which transports cholesterol into enterocytes from the intestinal lumen, and ABCG5/8, which transports cholesterol out of enterocytes into the gut lumen ( The TMA/FMO3/TMAO pathway driven by gut microbiota is also an important regulator of lipid metabolism (Warrier et al., 2015)
