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For B12 deficiency, only take the minimum amount needed to get your levels to normal.
doi: 10.1007/s40263-020-00781-x 104 HansonL
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Using an in vivo optical recording of neuronal activity, it has elegantly demonstrated that while stress-induced rapid activation and adaptation of the hypothalamic CRH neurons to the same stressors, their function in stress-free conditions was reduced by GCs [141]
