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Impaired bioenergetics of mitochondria in the colonic epithelium by high fat diet resulted in the increase of luminal bioavailability of oxygen and nitrate, thereby intensifying respiration-dependent choline catabolism of E

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For 31 P 3D-CSI spectral fitting, we used a spectral time-domain fitting program, based on the Marquardt-Levenberg nonlinear, least-squares algorithm, incorporating prior knowledge of spectral peak assignments, chemical-shifts, and J-coupling constants