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Monodehydroascorbate reductase in spinach chloroplasts and its participation in the regeneration of ascorbate for scavenging hydrogen peroxide

Under combined Gpx4 - and vitamin E-deficiency plasma EPO and ERFE levels increased to very high and highly significant levels (Figure 6P,Q), apparently mirroring the severity of erythropenia under combined Gpx4 - and vitamin E-deficiency.52 Taken together, the defect in reticulocyte maturation by loss of the Gpx4 gene causes ineffective erythropoiesis with simultaneous iron overload in the liver and iron-deficiency in the hematopoietic system and this phenotype is to a large part masked by vitamin E in the normal diet

The degree to which autophagy induction leads to observable enhancements in human metabolic health, especially among individuals with T2DM or metabolic syndrome, is still not fully understood [27]

Friedland, R