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Biochem Biophys Res Commun 209:227233 Mulcahy RT, Untawale S, Gipp JJ (1994) Transcriptional up-regulation of gamma-glutamylcysteine synthetase gene expression in melphalan-resistant human prostate carcinoma cells

Cell 149 (5), 10601072

Upon infection or invasion, enzymes break hCAP-18 down, releasing the active LL-37 peptide

In response to pathogen- or host-derived inflammatory signals (e.g., N -formylmethionyl-leucyl-phenylalanine (fMLP), interleukin (IL)-8, leukotriene B4, and complement component C5a), marginated neutrophils literally swarm to the site of infection [128]