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Description
Shaking creates mechanical stress and shearing forces that can break the fragile peptide bonds, rendering it useless
Plant-based synthesis has been demonstrated with Allophylus cobbe, Artemisia princeps, and Typha angustifolia (Gurunathan et al., 2014

Biochemical and cellular toxicology of peroxynitrite: implications in cell death and autoimmune phenomenon

doi: 10.1042/BST0331513