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doi: 10.1016/j.intimp.2023.111208 44 ZhangWSunZChengWLiXZhangJLiYet al

1 The initiation, also called priming, corresponds to the activation of the immediate-early response genes by pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF ) 2 and interleulin-6 (IL-6) 3 that induces the G0/G1 transition of quiescent hepatocytes

Similarly, as seen here, some patients with classical syndromes have low values [16]

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