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H., Chen J

This helps explain why patients with extensive surgical trauma or prolonged ischemia often develop a systemic inflammatory response that parallels septic shock, even in the absence of infection ( Importantly, these pathways offer targets for intervention: blocking upstream mtDAMPs release or downstream receptors could blunt the harmful inflammation

10.1038/nm.1277 87 TomsM.MarnP.MegasL.EgeaG.Renau-PiquerasJ

Simopoulos AP, Norman HA, Gillaspy JE, Duke JA
