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The uncoupling proteins, upregulated by mitochondrial respiration, can reduce the production of ROS and increase the resistance towards seizure
Mol Psychiatry (2008) 13:83357.10.1038/mp.2008.65 104 LawrenceNSWilliamsAMSurguladzeSGiampietroVBrammerMJAndrewCet alSubcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression
Pro-oxidant strategies could therefore serve as adjuncts to improve the efficacy of chemotherapy and reduce the development of resistance [108]
, Reference Nussinov2021
