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P21 has similarly shown the ability to reverse dendritic and synaptic density loss caused by traumatic brain injury, restoring the physical architecture of neural connections that had been damaged
It has been shown that the expression of 1C metabolism pathway genes is controlled by the same transcription factors as those which are involved in cancer progression [53]
A.AbobakerH.HouZ.YangS.et al (2020)
Conversely, when TREM2 was knocked out in 5xFAD mice, it exacerbated A pathology and neurodegeneration but reduced the numbers of Iba1+ cells
