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Description
In yeast, mitochondria-associated degradation (MAD)analogous to ERADensures proteostasis by extracting, ubiquitinating, and degrading misfolded mitochondrial proteins in the cytosol

TB-500 is being studied for muscle recovery and inflammation, but its lacking robust clinical evidence in humans

Its tolerability profile supports its use in patients with altered bowel motility, though we have no objective data confirming benefit in CIRS

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