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Severe toxicity cases are further defined as those involving significant cardiovascular complications (such as bradycardia, hypotension, sinus tachycardia requiring vasopressor support or intravenous fluids, or other dysrhythmias), respiratory issues (including respiratory failure, apnea, or the need for supplemental oxygen), or neurological impairments (such as seizures, myoclonus, unresponsiveness, responsiveness only to painful stimuli, or requiring intubation or sedative medication)

In contrast, Western-style diets, which are high in saturated fats and refined sugars, reduce microbial diversity and promote the growth of pro-inflammatory species such as Bilophila wadsworthia and Alistipes , contributing to chronic inflammation and metabolic dysregulation [18]

9, 2000, pp