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& Ziegler, T

The dose-response curve for neurotrophic factors is not linear, and more is not always better

GHK-Cu activates the TGF-/Smad signaling pathwaythe most potent endogenous stimulator of collagen productionwhile simultaneously enhancing production of connective tissue growth factor (CTGF) and FGF-2 that further amplify collagen expression

Patient titration over several weeks is preferable to jumping directly to higher doses
