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54 A negative APAP reading should not be interpreted as APAP-related hepatic injury having not taken place, as levels may be undetectable while liver damage has already occurred

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Metal-chelate affinity chromatography (Immobilized-metal (Ion) affinity chromatography) In 1970s, first application of metal-chelate affinity chromatography which is later named as "immobilized-metal (ion) affinity chromatography (IMAC) was perfomed

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