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Song SB, Park JS, Chung GJ, Lee IH, Hwang ES (2019) Diverse therapeutic efficacies and more diverse mechanisms of nicotinamide

5-Amino-1MQ has been investigated in preclinical models as a selective inhibitor of NNMT, an enzyme that catalyses the methylation of nicotinamide and has been referenced in the literature in connection with cellular energy metabolism, NAD + -associated signalling pathways, and energy homeostasis

NNMT inhibition significantly increases energy expenditure, reduces body weight and white adipose mass, and improves insulin sensitivity

That effect belongs to GLP-1 medications like semaglutide and tirzepatide