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Morphine-induced changes in cerebral and cerebellar nitric oxide synthase activity
Barriers to these characterizations hinge on the nature of the R-domain, which is predicted to be unstructured based on low sequence conservation 19 and experimentally confirmed with circular dichroism 19,20 and proteolysis analysis that estimate as low as 5% helical content 20
While it is not used for pigment removal alone, it helps improve texture, fine lines, and uneven tone when pigmentation is combined with aging or sun damage
