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The next day, desulfo-GSLs were eluted with 500 L MilliQ water for HPLC-UV measurement

FIGURE 1 Dopamine Metabolism Selective degeneration of the DA neurons of the SNpc suggests that DA itself may be a source of oxidative stress ( This oxidative process alters mitochondrial respiration and induces a change in the permeability transition pores in brain mitochondria ( Significant increases in cysteinyl adducts of L-DOPA, DA, and DOPAC have been found in substantia nigra of PD patients, suggesting the cytotoxic nature of DA oxidation ( Mitochondrial Dysfunction Mitochondrial dysfunction is closely related to increased ROS formation in PD ( Complex I deficiencies of the respiratory chain account for the majority of unfavorable neural apoptosis generation and is considered one of the primary sources of ROS in PD

H., Szmuilowicz, E