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In particular, using an allelic series of Col4a1 mutations, Jeanne and colleagues nicely demonstrated that the severity of the hemorrhagic phenotype was modulated by the position of the mutation, environmental factors (such as exercise) and the genetic background, findings which perfectly align with observations in patients (427)

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Eur J Mod Med Pract 4:373387 [Google Scholar] 74.Benites-Zapata VA, Ignacio-Cconchoy FL, Ulloque-Badaracco JR, Hernandez-Bustamante EA, Alarcn-Braga EA, Al-kassab-Crdova A, Herrera-Aazco P (2023) Vitamin B12 levels in thyroid disorders: a systematic review and meta-analysis